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KMID : 0363620090300060053
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 6 p.53 ~ p.68
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Neurological Effects of Bojungikki-tang and Bojungikki-tang-gamibang on Focal Cerebral Ischemia of the MCAO Rats
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Choi In-Seon
Kwon Jung-Nam
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Abstract
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Objectives: This study demonstrates the neurological effects of Bojungikki-tang and Bojungikki-tang-gamibang on the focal cerebral ischemia of rats with ischemic damage caused by middle cerebral artery occlusion (MCAO).
Methods: Rats were treated with Bojungikki-tang and Bojungikki-tang-gamibang extracts for about five days after MCAO, and the size and volume of cerebral infarction and the ratio of cerebral edema were observed. From the immunohistochemical view, significant changes of outbreak of Bax, Bcl-2, c-Fos, HSP72, and iNOS were observed in the brain tissues.
Results: Bojungikki-tang repressed only brain edema and iNOS revelation led by focal cerebral ischemia, when considering significance. In contrast, Bojungikki-tang-gamibang demonstrated significant suppression of cerebral infarction, brain edema, Bax, c-Fos, HSP72, and iNOS induced by focal cerebral ischemia.
Conclusions: Bojungikki-tang is considered functional treatment for cerebral ischemic damage; it can be effective to relieve secondary brain edema and immune response. Bojungikki-tang-gamibang can have a direct function to alleviate brain infarct and to control the natural death of nerve cells which cerebral ischemic damage brings about.
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KEYWORD
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Neurological effects, Bojungikki-tang (Bu xhong yi qi tang), Bojungikki-tang-gamibang (Jia wei Bu xhong yi qi tang), focal cerebral ischemia, MCAO rats
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